Registration Dossier
Registration Dossier
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EC number: 700-107-9 | CAS number: 87189-25-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is a macromolecule and is hydrolytically instable, resulting in cleavage of the molecule into zinc ions and glycerol. Other than the macromolecule, its cleavage products can be readily absorbed and enter systemic circulation. Accumulation is not expected but renal excretion might be the predominant elimination route.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Zinc, an essential element in the organism and a component of a number of enzymes and pays an important role in the immune system. It is crucial to the organism to maintain zinc homeostasis since there are no zinc stores per se. However, there is evidence that a small but rapidly exchangeable body pool of zinc does exist. Absorption and moreover excretion processes as well as coupling-decoupling with metallothionein regulate the zinc balance. The exact mechanism for the regulation is not fully understood. It can be concluded that unphysiologically high levels of zinc may be compensated by binding or excretion to some extent, and therefore may not cause overt toxicity. Adverse findings however can not be excluded if levels of zinc are present above the saturation of processes. On the other hand, there is clear evidence that zinc deficiency causes adverse impairment of fertility and foetal development.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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