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EC number: 235-243-3
CAS number: 12138-09-9
No skin sensitisation toxicity data of
sufficient quality is available for tungsten disulphide (target
substance). However, a skin sensitisation study for tungsten metal
(source substance) is available, which was used for reading across.
Because of similar water solubility and toxicity, the resulting read
across from the source substance to the target substance is appropriate
to estimate the potential toxicity for this endpoint. For more details,
refer to the attached description of the read-across approach.
skin sensitisation test of sufficient quality and tested in accordance
with standard methodology (OECD 406) was available for tungsten metal.
The results of this study showed that tungsten metal did not cause skin
sensitization in the Guinea Pig. Therefore,
no skin sensitization for tungsten disulphide is expected.
Dermal reactions seen following the induction:
- Intradermal injections:
Necrosis was recorded at most sites receiving Freund's Complete Adjuvant
in both test and control animals.
Slight irritation was seen in most test animals at sites receiving
Tungsten metal powder (20% w/v) in sterile water. No irritation was
observed in control animals receiving sterile water for injection.
Slight erythema was observed in most test animals following topical
application with Tungsten metal powder, 70% w/v in distilled water.
Slight erythema was also seen in most of the control guinea-pigs after
topical application of distilled water alone.
- Dermal reactions elicited by the challenge applications:
No dermal reactions were seen in any of the test or control animals.
Bodyweight increases were recorded for all guinea pigs over the period
of the study.
No signs of ill health or toxicity were recorded.
No skin sensitisation data of sufficient quality are available for
tungsten disulphide (target substance). However, skin sensitisation data
are available for tungsten metal (source substance), which will be used
for reading across. Due to similar water solubility and toxicity for the
target substance compared to the source substance, the resulting read
across from the source substance to the target substance is appropriate.
In addition, read across is appropriate because the classification and
labelling is similar for the source substance than the target substance,
the PBT/vPvB profile is the same, and the dose descriptors are, or are
expected to be, lower for the source substance. For more details, refer
to the read-across category approach included in the Category section of
this IUCLID submission and/or as an Annex in the CSR.
skin sensitisation data of sufficient quality is available for tungsten
disulphide (target substance). However, a skin sensitisation study is
available for tungsten metal (source substance), which was used for
reading across. The results of
this study showed that tungsten metal did not cause skin sensitisation
in the Guinea Pig. Therefore, no classification is required for the skin
sensitisation endpoint for tungsten disulphide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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