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EC number: 235-243-3
CAS number: 12138-09-9
INDIVIDUAL EYE IRRITATION SCORES
Time after dosing
TABLE 2: MEAN VALUE EYE IRRITATION SCORES
The study was carried out based on the guidelines described in: EC
Commission Directive 92/69/EEC, B.5, "Acute Toxicity - Eye irritation"
and OECD No.405, "Acute Eye Irritation/Corrosion".
Single samples of
approximately 94 mg of TUNGSTEN DISULFIDE (a volume of approximately 0.1
ml) were instilled into one eye of each of three rabbits. Observations
were made 1, 24, 48 and 72 hours after instillation.
Instillation of the
test substance resulted in effects on the iris and conjunctivae.
lridial irritation (grade 1) was observed in all animals and had
resolved within 24 hours. Irritation of the conjunctivae was seen as
redness, chemosis and discharge, which had completely resolved within 48
hours in all animals. Grey staining of (peri) ocular tissues by the test
substance was observed on day 1. Due to this staining, the eyelids,
nictitating membrane and sclera could be scored partly (upper part).
Remnants of the test substance were present in the eyes of two
animals on days 1 and 2 and in one animal on day 1. Remnants of the test
substance were present on the outside of the eyelids of two animals on
days 1 and 2 and of one animal on day 1. Grey staining of the fur on the
head and paws, caused by the test substance, was noted on day 1.
Based on these
results and according to the EC criteria for classification and
labelling requirements for dangerous substances and preparations
(Guidelines in Commission Directive 93/21/EEC), TUNGSTEN DISULFIDE does
not have to be classified and has no obligatory labelling requirement
for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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