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EC number: 235-243-3
CAS number: 12138-09-9
acute dermal toxicity data of sufficient quality are available for
tungsten disulphide (target substance). However, acute dermal toxicity
data are available for tungsten metal (source substance), which will be
used for reading across. Similar water solubility and lower toxicity for
the target substance compared to the source substance, the resulting
read across from the source substance to the target substance is
appropriate to estimate of potential toxicity for this endpoint. For
more details, refer to the attached description of the read-across
approach. An acute dermal toxicity study on tungsten metal
(source substance) conducted according to OECD 402 reported no deaths
and no evidence of a systemic response in any animal throughout the
study following a single dermal application of the test substance to
rats at a dose level of 2000 mg/kg-bw. The acute lethal dose was
determined to be greater than 2000 mg/kg bw.
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