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EC number: 235-243-3
CAS number: 12138-09-9
The acute inhalation toxicity of tungsten disulphide was studied
by nose-only exposure of one group of five male and five female rats for
a 4-hour period to a test atmosphere containing an aerosol of tungsten
disulphide at the limit concentration of 5.25 ± 0.13 g/m3•The
Mass Median Aerodynamic Diameter of the particles in the test atmosphere
was measured once before and once during exposure and yielded 2.7 and 3.0µm,
respectively. The distribution of particle sizes had a
geometric standard deviation of 1.9 in both instances. After exposure,
the animals were kept for a 14-day observation period. Clinical signs
during exposure consisted of a slightly decreased breathing rat in right
animals as well as labored breathing in one animal. All animls felt cold
after exposure and had a black discoloration on their heads. The overall
body weight gain in males were considered to be within normal limts.
body weight gain in females was considered to be within normal limits
during the first week of the observation period, and low during the
second week of the observation period.
No mortality occurred during exposure or during the
14 -day observation period.The
4-hour LC50 value of an aerosol of tugsten disulphide was larger than 5.25
g/m3 for both
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