Registration Dossier
Registration Dossier
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EC number: 232-245-6 | CAS number: 7791-25-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Original report not available - information taken from OECD SIDS. Basic data given, peer reviewed; Although the documentation is limited, this study meets generally accepted scientific principles and is acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- secondary source
- Title:
- Sulfuryl chloride CAS No. 7791-25-5, SIDS Initial assessment report
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP publications
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- other: abstract
- Title:
- Acute and subacute inhalation toxicity of sulfuryl chloride in rats.
- Author:
- Kelly, D.P. & Stula, E.F.
- Year:
- 1 983
- Bibliographic source:
- Toxicologist 3, 62, Abstr. 248
Materials and methods
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sulphuryl dichloride
- EC Number:
- 232-245-6
- EC Name:
- Sulphuryl dichloride
- Cas Number:
- 7791-25-5
- Molecular formula:
- Cl2O2S
- IUPAC Name:
- sulfuroyl dichloride
- Details on test material:
- - Name of test material (as cited in study report): Sulfuryl chloride vapor
- Purity: ca. 100 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- head only
- Vehicle:
- other: no
- Duration of exposure:
- 4 h
- Concentrations:
- 84.4, 134, 155, 207, or 273 ppm (0.46, 0.74, 0.85, 1.14, or 1.50 mg/l)
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 878 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- 0.46 mg/l: 0/10 0.74 mg/l: 2/10 (1 death during exposure, 1 death within 24 hours) 0.85 mg/l: 8/10 (6 deaths during exposure, 2 deaths within 24 hours) 1.14 mg/l: 7/10 (7 deaths during exposure) 1.50 mg/l: 10/10 (10 deaths during exposure)
- Clinical signs:
- other: During exposure all rats showed red nasal and ocular discharge. At >= 0.85 mg/l a foamy nasal discharge was noted. In surviving animals reduced body weights were observed 1-2 days following exposure. Also pallor, dry red ocular discharge, wet perineum, dr
- Gross pathology:
- NECROPSY FINDINGS: no data
Any other information on results incl. tables
LC50: 159 ppm (original value)
exposure to sulfuryl chloride vapours
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
