Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Original report not available - information taken from OECD SIDS. Basic data given, peer reviewed; Although the documentation is limited, this study meets generally accepted scientific principles and is acceptable for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1982
Reference Type:
secondary source
Title:
Sulfuryl chloride CAS No. 7791-25-5, SIDS Initial assessment report
Author:
OECD
Year:
2002
Bibliographic source:
UNEP publications
Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Reference Type:
other: abstract
Title:
Acute and subacute inhalation toxicity of sulfuryl chloride in rats.
Author:
Kelly, D.P. & Stula, E.F.
Year:
1983
Bibliographic source:
Toxicologist 3, 62, Abstr. 248

Materials and methods

Principles of method if other than guideline:
Method: no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Sulfuryl chloride vapor
- Purity: ca. 100 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
head only
Vehicle:
other: no
Duration of exposure:
4 h
Concentrations:
84.4, 134, 155, 207, or 273 ppm (0.46, 0.74, 0.85, 1.14, or 1.50 mg/l)
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
878 mg/m³ air
Exp. duration:
4 h
Mortality:
0.46 mg/l:  0/10 0.74 mg/l:  2/10 (1 death during exposure, 1 death within 24 hours) 0.85 mg/l:  8/10 (6 deaths during exposure, 2 deaths within 24 hours) 1.14 mg/l:  7/10 (7 deaths during exposure) 1.50 mg/l: 10/10 (10 deaths during exposure)
Clinical signs:
other: During exposure all rats showed red nasal and ocular discharge. At >= 0.85 mg/l a foamy nasal discharge was noted. In surviving animals reduced body weights were observed 1-2 days following exposure. Also pallor, dry red ocular discharge, wet perineum, dr
Gross pathology:
NECROPSY FINDINGS: no data

Any other information on results incl. tables

LC50: 159 ppm (original value)
exposure to sulfuryl chloride vapours

Applicant's summary and conclusion