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EC number: 213-603-0
CAS number: 993-07-7
Gene mutation (Bacterial reverse mutation assay / Ames test): negative
with and without metabolic activation in Salmonella typhimurium
TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2 uvrA / pKM101
(OECD TG 471) (Japan Bioassay Research Center 2001a).
Cytogenicity in mammalian cells: negative with and without metabolic
activation in Chinese hamster lung IU cells (OECD TG 473) (Japan
Bioassay Research Center 2001b).
Trimethylsilane has been tested in a study conducted according to a
national standard (Japanese) method that is similar to OECD 471, and in
compliance with GLP (Japan Bioassay Research Center 2001a). No increase
in the number of revertants was observed in the presence or absence of
metabolic activation when tested using the gas exposure method at
concentrations up to 50%. The observations made in the initial
dose-ranging study were reproduced in the main test. The strains tested
were Salmonella typhimurium TA 1535, TA 1537, TA 98, TA 100 and E.
coli WP2 uvrA / pKM101, and duplicate plates were used. Appropriate
vehicle (air) and positive controls were used and gave expected
responses; only 2-aminoanthracene was used as positive control with
Trimethylsilane has been tested according to a national standard method
(Japanese) that is equivalent to OECD 473, and in compliance with GLP.
No increase in the incidence of chromosome aberrations was observed when
tested using a gas exposure method at concentrations up to 80% with and
without metabolic activation in Chinese hamster lung cells. Appropriate
vehicle and positive controls were used and gave expected results. It is
concluded that the test material is negative for the induction of
chromosome aberrations under the conditions of the test.
Based on the available in vitro genotoxicity data,
trimethylsilane is not classified for mutagenicity according to
Regulation (EC) No 1272/2008.
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