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EC number: 213-603-0
CAS number: 993-07-7
Biodegradation in water (screening tests): 0.7% in 28 days (OECD 301D; EU Method C4-E), read-across from an analogous/structurally related substance.
is expected to hydrolyse in water within the timescale of the ready
biodegradation study (half-life of about 3 days
24.7°C in well water) to form trimethylsilanol and hydrogen.
are no reliable ready biodegradation data available for the registration
substance trimethylsilane (CAS No: 993-07-7), therefore good quality
data for the silanol hydrolysis product, tetramethylsilane (CAS No: 75
-76 -3) has been used to assess this endpoint.
is an inorganic gas and biodegradation study is therefore not relevant.
(CAS No 993 -07 -7) and tetramethylsilane (CAS No. 75-76-3) are within an
analogue group of substances within which, in general, there is no
evidence of any significant biodegradation once hydrolysis and
subsequent biodegradation of alkoxy/acetoxy groups has been taken into
account. In this case, neither substance contains such a group.
analogue group for the ready biodegradability endpoint consists of a
number of sub-classes of substances (based on structure/functionality)
with different main codes (used to represent the different sub-classes).
However, read-across is carried out between substances with the same
main code in most cases.
table below presents ready biodegradation data for substances within the
sub-class[I-1] of silanes.Trimethylsilane
(CAS No 993 -07-7) and tetramethylsilane (CAS No. 75-76-3) are
members of this class.
is therefore considered valid to read-across the results for
tetramethylsilane (CAS No. 75-76-3) to fill the data gap for the
registered substance. Additional
information is given in a supporting report (PFA,
in Section 13.
Table: Ready biodegradation data for substances within the
relevant sub-class [I-1] of chemicals
Readily biodegradable? Yes/no
Result: Biodegradation after 28 day
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for
the study with tetramethylsilane (CAS No. 75-76-3), 0.7% biodegradation
was observed in 28 days.
significant biodegradation is expected for the silanol hydrolysis
study was conducted according to OECD 301D and is considered reliable.
This is selected as the key study.
study is considered to be reliability 1 (reliable without restrictions);
the read across of the result is considered to be reliability 2
(reliable with restrictions).
PFA, 2013f, Peter Fisk Associates, Biodegradation Main Analogue Group
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