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EC number: 431-620-3
CAS number: 162537-11-3
A study was performed to assess the irritancy potential of the test
material to the eye of the New Zealand White rabbit. The method used
followed that described in the OECD Guidelines for Testing of Chemicals
No.405 "Acute Eye Irritation/Corrosion" (adopted 24 February 1987) and
Method B5 of Commission Directive 92/69/EEC (which constitutes Annex V
of Council Directive 67/548/EEC).
The results may be used as a basis for classification and labelling
under Annex VI of Council Directive 67/548/EEC (as adapted to technical
progress by Commission Directive 93/21/EEC) relating to the
classification, packaging and labelling of dangerous substances.
A single application of the test material to the non-irrigated eye of
one rabbit produced translucent corneal opacity, iridial inflammation
and moderate conjunctival irritation. Other ocular effects noted were
vascularisation of the cornea, a pale appearance of the nictitating
membrane, petechial haemorrhage of the nicitating membrane and
ectroption. The persistence of vascularisation at the 21-day observation
was considered to be an irreversible effect.
The test material produced a maximum total score of 37.0 but was
considered to be corrosive to the rabbit eye due to irreversible effects.
The test material was also considered to be irritant according to EU
labelling regulations. It is reasonable to assume that the symbol "Xi"
and highest risk phrase R41 "Risk of serioud damage to eyes" are
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