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EC number: 431-620-3
CAS number: 162537-11-3
A study was performed to assess the acute dermal toxicity of the test
material in the Sprague-Dawley CD strain rat. The method used followed
that described in the OECD Guidelines for Testing of Chemicals No 402
"Acute Dermal Toxicity" (adopted 24 February 1987) and Method B3 of
Commission Directive 92/69/EEC (which constitutes Annex V of Council
The results may be used as a basis for classification and labelling
under Annex VI of Council Directive 67/548/EEC (as adapted to technical
progress by Commission Directive 93/21/EEC) relating to the
classification, packaging and labelling of dangerous substances.
A group of ten animals (five males and five females) was given a single
24-hour, semi-occluded dermal application to intact skin at a dose level
of 2000 mg/kg bodyweight. The animals were observed for fourteen days
after the day of treatment and were then killed for gross pathological
There were no deaths. No signs of systemic toxicity or dermal irritation
were noted during the study.
All animals showed an expected gain in bodyweight during the study.
No abnormalities were noted at necropsy.
The acute dermal median lethal dose (LD50) of the test material in the
Sprague-Dawley CD strain rat was found to be greater than 2000 mg/kg
bodyweight. No symbol and risk phrase are required according to EU
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