Registration Dossier
Registration Dossier
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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- Type of study / information:
- Single exposure, Inhalation, controlled exposure, Irritation
CNS effects - Endpoint addressed:
- eye irritation
- neurotoxicity
- other: CNS effects
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Stoddard solvent vapour (17% aromatics).
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
- Exposure assessment:
- measured
- Details on exposure:
- nine volunteers (students) were exposed to 0, 204, 600, 1200 and 2400 mg/m3 (0, 34, 100, 200 and 400 ppm) and six students and nine painters were exposed to 0, 300 and 600 mg/m3 (0, 50 and 100 ppm) for a duration of 7 h to white spirit vapour (17% aromatics).
Results and discussion
- Results:
- The reporting of eye irritation was the most sensitive measure of effect. There was a significant dose-response relationship in the house painter group and in one group of students exposed up to 2400 mg/m3; there was a higher sensitivity in the house painters. Among students, a dose-related increase in irritation of the nose was noted from 600 to 2400 mg/m3.
In the study was found dose-related increased incidences of headache, tiredness and giddiness among nine students exposed up to 2400 mg/m3 (400 ppm).
Applicant's summary and conclusion
- Conclusions:
- The reporting of eye irritation was the most sensitive measure of effect. There was a significant dose-response relationship in the house painter group and in one group of students exposed up to 2400 mg/m3; there was a higher sensitivity in the house painters. Among students, a dose-related increase in irritation of the nose was noted from 600 to 2400 mg/m3.
In the study was found dose-related increased incidences of headache, tiredness and giddiness among nine students exposed up to 2400 mg/m3 (400 ppm).
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