Stoddard solvent

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Chronic toxic encephalopathy in solvent-exposed painters in Denmark 1976-1980: Clinical cases and social consequences after a 5-year follow-up.

Author:

Gregersen P, Klausen H, & Elsnab CU

Year:

1987

Bibliographic source:

Am J Ind Med, 11: 399-417.

Materials and methods

Type of sensitisation studied:

respiratory

Study type:

case report

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

In a 5-year follow-up study was described the social consequences for 21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Stoddard solvent

EC Number:

232-489-3

EC Name:

Stoddard solvent

Cas Number:

8052-41-3

Molecular formula:

C10H22

IUPAC Name:

stoddard solvent

Test material form:

liquid

Method

Type of population:

occupational

Ethical approval:

confirmed, but no further information available

Subjects:

21 painters

Clinical history:

21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.

Route of administration:

inhalation

Details on study design:

In a 5-year follow-up study was described the social consequences for 21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.

Results and discussion

Results of examinations:

At the time of diagnosis all the painters had given up their job and five years later 11 worked in other jobs while 10 were receiving the highest disability pension. Clear differences were noted between those who were still working and those who were awarded a pension. The former group were considerably younger, had a history of lower exposure and were less impaired in their intellectual functioning.

Applicant's summary and conclusion

Conclusions:

At the time of diagnosis all the painters had given up their job and five years later 11 worked in other jobs while 10 were receiving the highest disability pension. Clear differences were noted between those who were still working and those who were awarded a pension. The former group were considerably younger, had a history of lower exposure and were less impaired in their intellectual functioning.