Stoddard solvent

Epidemiological data

Administrative data

Endpoint:

epidemiological data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Psychological function changes among maintenance house painters exposed to low levels of organic solvent mixtures.

Author:

Lindström K & Wickström G

Year:

1983

Bibliographic source:

Acta Psychiatr Scand, 67(suppl 303): 81-91.

Materials and methods

Study type:

cross sectional study

Endpoint addressed:

basic toxicokinetics

acute toxicity: inhalation

repeated dose toxicity: inhalation

neurotoxicity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Cross-sectional study. Questionnaire. 8 neuropsychological tests determining intelligence and psychomotor performance

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Stoddard solvent

EC Number:

232-489-3

EC Name:

Stoddard solvent

Cas Number:

8052-41-3

Molecular formula:

C10H22

IUPAC Name:

stoddard solvent

Test material form:

liquid

Method

Type of population:

occupational

Ethical approval:

confirmed, but no further information available

Details on study design:

In a cross-sectional study, 219 housepainters and 229 reinforcement workers were assessed using 8 neuropsychological tests to determine intelligence and psychomotor performance. The mean exposure period was 22 years with an estimated average level of white spirit of 40 ppm (232 mg/m³) during working hours; exposure indices made for total lifetime exposure and average exposure levels.

Exposure assessment:

measured

Details on exposure:

Mexp. 22 years with an estimated average level of white spirit of 40 ppm during working hours; exposure indices made for total life-time exposure and average exposure levels

Results and discussion

Results:

Among painters, there were significantly increased prevalence of acute symptoms such as nausea, runny noses and malaise. Short-term visual memory and simple reaction time were affected, however, when pre-exposure intellectual level was taken into account, the painters performed more poorly only in the visual memory test.

Applicant's summary and conclusion

Conclusions:

In a cross-sectional study, 219 housepainters and 229 reinforcement workers were assessed using 8 neuropsychological tests to determine intelligence and psychomotor performance. The mean exposure period was 22 years with an estimated average level of white spirit of 40 ppm (232 mg/m³) during working hours; exposure indices made for total lifetime exposure and average exposure levels. Among painters, there were significantly increased prevalence of acute symptoms such as nausea, runny noses and malaise. Short-term visual memory and simple reaction time were affected, however, when pre-exposure intellectual level was taken into account, the painters performed more poorly only in the visual memory test.