Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented company data which meets basic scientific principles

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
company data, no method was mentioned
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
EC Number:
604-045-2
Cas Number:
137862-53-4
Molecular formula:
C24 H29 N5 O3
IUPAC Name:
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine

Results and discussion

Water solubility
Water solubility:
0.8 g/L
Temp.:
25 °C
pH:
3.8

Any other information on results incl. tables

Solvent

Temp (°C)

Resulting pH

Solubility (g/L)

water

25

3.8

0.18

0.2 M NaCl

25

3.8

0.18

0.1 N HCl

22

1.12

0.084

0.01 M glycine buffer, pH = 3

22

3.05

0.104

0.067 M phosphate buffer, pH = 5.2

22

4.41

0.64

0.067 M phosphate buffer, pH = 6.0

22

4.90

2.82

0.067 M phosphate buffer, pH = 7.4

22

5.26

14.4

0.067 M phosphate buffer, pH = 8.0

22

5.29

16.8

water

37

3.8

0.21

0.01 N HCl

37

1.0

0.10

Applicant's summary and conclusion