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EC number: 811-213-0
CAS number: 66711-86-2
purpose of this inhalation study was to assess the cumulative toxicity
of the test substance when administered 6 hours daily and 5 days per
week to rats by nose-only, flow-past inhalation exposure for a period of
28 days. The reversibility or progression of any test substance related
effects or any delayed toxicity was assessed during a 2-week exposure
free recovery period. In addition, potential genotoxicity was
investigated by the evaluation of micronuclei level in the blood. Groups
of 10 male and 10 female Wistar rats each were exposed by nose-only
flow-past inhalation to target concentrations of 1000, 10000 and 20000 /
15000 ppm test substance in each of groups 2 to 4, respectively. The
rats of the control group were exposed to filtered air only (group 1).
An additional 5 male and 5 female rats were kept for a 2-week recovery
period. Mortality, clinical signs, functional observation battery, grip
strength, body temperature, locomotor activity, body weights, food
consumption, clinical laboratory investigations, micronucleus
evaluation, organ weights, macroscopic and microscopic findings were
to chemically determined atmosphere concentrations of 1000, 10010 and
20239 / 15076 ppm test substance were achieved in groups 2 to 4,
respectively, and were close to the respective targets. Temperature,
relative humidity and oxygen concentration during exposure were
considered to be suitable for this type of study.
test substance did not induce micronuclei as determined by the
micronucleus test in peripheral blood cells on day 4 or at the end of
exposure. Therefore, the test substance was considered to be
non-mutagenic in this micronucleus assay under the experimental
conditions of this study. No effects on the organ weights and no gross
or microscopic findings were observed that were considered to be related
test item did not induce micronuclei as determined by the micronucleus
test in peripheral blood cells. Therefore, the test item was considered
to be non-mutagenic in this micronucleus assay under the experimental
conditions of this study.
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