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EC number: 811-213-0
CAS number: 66711-86-2
Two groups of 5 male and 5 female
Crl:CD(SD) rats each were exposed whole-body to vapours of the test
substance in air. Test atmospheres were generated by dilution of the
test substance vapour in air. Chamber concentrations of the test
substance were measured by a gas chromatograph. Rats were weighed and
observed for clinical signs of toxicity during a 14-day recovery period.
After the recovery period, the rats were sacrificed and examined for
gross pathologic abnormalities. All animals survived the exposures and
subsequent 14-day recovery period.
For the initial exposure, rats were
exposed for 4 hours to a mean concentration of 17000 ± 250 ppm (mean ±
standard deviation). Approximately 6 minutes after the exposure started,
the rats displayed decreased activity, which continued throughout the
exposure; however, the rats’ startle responses were normal throughout
the 4-hour exposure. Three male rats displayed weight loss ranging from
1.9 to 5.7 grams on the day after the exposure. Four of 5 female rats
lost weight (from 2.2 to 8.4 grams) on the day following the exposure,
and one female continued to lose weight (6.0 grams) on post-exposure day
2. All female rats gained weight on post-exposure day 3, but one female
rat lost 6.4 grams and another lost 8.4 grams on post-exposure day 4.
There were no other weight losses or clinical signs of toxicity observed
in any rats during the 14-day recovery period.
Based on the results of the first
exposure, a design concentration of approximately 25000 ppm was set for
a second exposure. Within 2 minutes of initiating the test substance
vapour flow, the rats displayed decreased activity. The rats began to
display muscular spasms approximately 5 minutes into the exposure,
followed by violent convulsions occurring 8 minutes into the exposure.
The vapour flow was terminated 8 minutes after the exposure started. The
chamber concentration peaked at 25000 ppm; the mean chamber
concentration for the 8-minute exposure was 23000 ppm. Within 17 minutes
of when the test substance vapour was shut off, the rats displayed
normal startle response and had no abnormal clinical signs of toxicity.
There were no clinical signs of toxicity observed throughout the 14-day
recovery period. Four of 5 female rats lost between 5.5 and 10.1 grams
on the day after the exposure. There were no other body weight losses
observed in any rats throughout the entire recovery period. Gross
discoloration of the lungs present in two female rats in the 23000 ppm
group, was nonspecific, and is a common finding in rats of this strain
and age. No other gross lesions were observed.
Under the conditions of this study, the
4-hour LC50 for vapour atmospheres of the test substance
in male and female rats was greater than 17000 ppm. An 8-minute exposure
to approximately 23000 ppm caused the rats to display violent
convulsions and therefore was terminated for humane reasons.
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