Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
assessment report
GLP compliance:
yes
Key result
Duration:
4.75 h
Dose descriptor:
EC10
Effect conc.:
> 915 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Remarks on result:
other: corrected for the molecular weight of the target substance: maximum weight source substance: 630.94 g/mol
Duration:
4.75 h
Dose descriptor:
EC10
Effect conc.:
> 1 060 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Remarks on result:
other: corrected for the molecular weight of the target substance: minimum weight: source substance: 543.76 g/mol;
Validity criteria fulfilled:
yes
Conclusions:
The test substance was not toxic under test conditions in the range of water solubility.
Executive summary:

The study used as source investigated bacteriotoxicity of 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters according to a method developed by the testing laboratory. The test substance did not affect the bacterial respiration and derived effect concentration were: 4.75h-EC10 > 0.9 g a.i./L, 4.75h-EC50 > 915 -1060 mg a.i./L (corrected for the molecular weight of the target substance). Results of the source compound were considered applicable to the target compound. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross-reference “assessment report”.

Description of key information

No microorganism toxicity data for the submission substance is available. However adequate and reliable data for structural analogues is available (i.e. C8C10TM, for read-across justification please see read-across report in section 13).The derived 4.75h-EC10 (Pseudomonas putida, respiration) > 915 -1060 mg a.i./L (corrected for the molecular weight of the target substance).

Key value for chemical safety assessment

Additional information

No microorganism toxicity data for the submission substance is available. However adequate and reliable data for structural analogues (i.e. C8C10TM, for read-across justification please see read-across report in section 13) are reported below.

In a reliable toxicity study on microorganism (non-guideline study and in compliance with GLP, Huels AG, 1994, RL2), no effect on respiration (biochemical oxygen demand) was observed during 4.75 hours of exposure to three concentrations up to 980 mg a.i./L test substance (nominal 1000 mg/L, use of solubilizer, analogue substance: 1,2,4-benzenetricarboxylic acid, mixed decyl and octyl triesters, C8C10TM, CAS no. 90218-76-1) (corresponding to 915 - 1060 mg/L of the target substance). No analytical verification of the test concentrations was performed. No toxicity to microorganisms is expected below the water solubility of the analogue and submission substance.

Categories Display