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EC number: 252-552-9
CAS number: 35415-27-1
The study used as source reference investigated acute toxicity to
daphnids (Daphnia magna) during 48 hours of exposure according to OECD
202 and in compliance with GLP. The 48h-LC50 (Daphnia magna, immobility)
was determined to be >108 mg/L (corrected for the molecular weight of
the target substance). The validity criteria of the test guideline were
fulfilled and results of the source compound were considered applicable
to the target compound. Justification and applicability of the
read-across approach (structural analogue) is outlined in the
read-across report in section 13 or find a link in cross-reference
No acute toxicity data on aquatic invertebrates for the submission substance is available. However adequate and reliable data for structural analogues is available (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13). The derived 48h-EC50 (Daphnia magna, immobility) > 108 mg/L (corrected for the molecular weight of the target substance).
No acute aquatic toxicity data for the submission substance is
available. However adequate and reliable data for structural analogues
(i.e. C8TM and C8C10TM, for read-across justification please see
read-across report in section 13) are reported below.
In a reliable acute toxicity study on daphnids (according to OECD 202
and in compliance with GLP, MoE Japan, 2001, RL1) no significant
immobility was observed in a limit test at 100 mg/L test substance
(analogue substance: trioctyl benzene-1,2,4-tricarboxylate, trioctyl
ester, C8TM, CAS no. 89-04-3; corresponding to 108 mg/L of the target
substance). Furthermore, no significant immobility was observed in the
supporting studies (EU Method C.2, GLP, Huels AG, 1994, RL2 and ICI GEL,
1990, RL4) in a limit test at 4.4 mg/L and 1 mg/L test substance
(analogue substance: 1,2,4-benzenetricarboxylic acid, mixed decyl and
octyl triesters, C8C10TM, CAS no. 90218-76-1; corresponding to 4.1 -4.8
mg/L and 1 mg/L of the target substance). In conclusion, no acute
toxicity to daphnia is expected below the water solubility of the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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