Trinonyl benzene-1,2,4-tricarboxylate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

assessment report

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

< 108 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: N/A, limit test

Remarks:

corrected for the molecular weight of the target substance

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 108 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: N/A, limit test

Remarks:

corrected for the molecular weight of the target substance

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 108 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: N/A, limit test

Remarks:

corrected for the molecular weight of the target substance

Validity criteria fulfilled:

yes

Conclusions:

The 96h-LC50 (Oryzias latipes, mortality) was >108 mg/L (corrected for the molecular weight of the target substance).

Executive summary:

The study used as source investigated acute toxicity to fish (Oryzias latipes) during 96 hours of exposure according to OECD 203 and in compliance with GLP. The 96h-LC50 (Oryzias latipes, mortality) was determined to be >108 mg/L (corrected for the molecular weight of the target substance). The validity criteria of the test guideline were fulfilled and results of the source compound were considered applicable to the target compound. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross-reference “assessment report”.

Description of key information

No acute toxicity data on fish for the submission substance is available. However adequate and reliable data for structural analogues is available (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13). The derived 96h-LC50 (Oryzias latipes, mortality) was >108 mg/L (corrected for the molecular weight of the target substance). 

Additional information

No acute aquatic toxicity data for the submission substance is available. However adequate and reliable data for structural analogues (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13) are reported below.

 

In a reliable acute toxicity study on fish (according to OECD 203 and in compliance with GLP, MoE Japan, 2001, RL2) no mortality was observed in a limit test at 100 mg/L test substance (analogue substance: trioctyl benzene-1,2,4-tricarboxylate, trioctyl ester, C8TM, CAS no. 89-04-3; corresponding to 108 mg/L of the target substance). Furthermore, no mortality was observed in the supporting study (EU Method C.1, GLP, Huels AG, 1994, RL2) in a limit test at 3 mg/L test substance (analogue substance: 1,2,4 -benzenetricarboxylic acid, mixed decyl and octyl triesters, C8C10TM, CAS no. 90218-76-1; corresponding to 3 mg/L of the target substance). In conclusion, no acute toxicity to fish is expected below the water solubility of the submission substance.