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EC number: 810-533-8
CAS number: 330459-31-9
four week dermal toxicity study in Sprague-Dawley rats was conducted at
concentrations of 0, 100, 300, and 1,000 mg/kg bw/day test substance
according to OECD Guideline 410 and OPPTS 870.3200, in compliance with
GLP. Ten males and ten females per dose group were used. Test substance
moistened with the vehicle (deionized water) was applied topically under
occlusive conditions to the shaved intact dorsal surface of three groups
of rats once daily for 6 h for up to 28 consecutive days. A concurrent
control group received the vehicle on a comparable regimen. There were
no test substance-related effects on survival, dermal observations,
haematology, coagulation, ophthalmic examinations and macroscopic
observations. Treatment-related lower mean cumulative body weight gains
were observed in the 300 and 1,000 mg/kg bw/day group males and females.
Also adrenal cortical cytoplasmic vacuolation were observed in the 300
mg/kg bw/day group males and 1,000 mg/kg bw/day group males and females.
Hence, the NOAEL was considered to be 100 mg/kg bw/day (Mertens JJWM,
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