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EC number: 810-533-8
CAS number: 330459-31-9
90 d dietary study in Sprague-Dawley rats was conducted at
concentrations of 0, 10, 50, 250, 750 and 1,500 ppm test substance (i.
e., equivalent to 0, 1, 3, 16, 47 and 91 mg a.i./kg bw/day for males and
0, 1, 4, 19, 55 and 113 mg a.i./kg bw/day for females) according to OECD
Guideline 408 and OPPTS 870.3100, in compliance with GLP. This included
evaluation of potential neurotoxicity by functional observational
battery (FOB) and motor activity assessments. Ten males and 10 females
per dose group were used. Adverse effects included haematological
differences noted at 1,500 ppm (females only), tubular hyperplasia noted
microscopically at 1,500 ppm, and metaphyseal hyperostosis noted
microscopically in the femoral bone at ≥750 ppm. Under the conditions of
this study, the NOAEL for systemic toxicity of the test substance in rat
was considered to be 250 ppm (equivalent to 16 and 19 mg/kg bw/day for
males and females, respectively) (Kirkpatrick JB, 2013).
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