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Long-term toxicity to fish

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Description of key information

Under the study conditions, NOEC and LOEC for the test substance, based on mean, measured test concentrations, and post-hatch survival were 9.4 and 24 μg a.i./L, respectively.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.009 mg/L

Additional information

A study was conducted to determine the effect of the test substance on the time to hatch, hatching success, survival, and growth of fathead minnows,Pimephales promelas, during early life-stage development, according to ASTM Standard E-1241 -05, FIFRA Subdivision E, Section 72 -4a, OECD Guideline 210 and OPPTS 850.1400, in compliance with GLP.Fathead minnow embryos were exposed to a geometric series of six test concentrations of 0.26, 0.64, 1.6, 4.0, 10 and 25 μg a.i./L (mean, measured concentrations of 0.23, 0.59, 1.5, 3.7, 9.4 and 24 μg a.i./L), a negative (dilution water) control and a solvent control (0.02 mL/L HPLC-grade dimethylformamide) under flow-through conditions. The exposure period included a 5 d embryo hatching period, and a 28 d post-hatch juvenile growth period.No statistically significant treatment related effect on hatching success was found at 24 μg a.i./L. A statistically significant reduction in post-hatch survival was found at 24 μg a.i./L. There were no significant treatment-related effects on growth at concentrations ≤9.4 μg a.i./L. Under the study conditions, NOEC and LOEC for the test substance, based on mean, measured test concentrations, and post-hatch survival were 9.4 and 24 μg a.i./L, respectively. The maximum acceptable toxicant concentration (MATC) was calculated to be 15 μg a.i./L (Minderhout T, 2013).