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EC number: 810-533-8
CAS number: 330459-31-9
The 96 h LC50 value for the test substance was determined as 76 μg a.i./L, with a 95% confidence interval of 59 to 108 μg a.i./L.
study was conducted to assess the effects of the test substance on
rainbow trout (Oncorhyncus mykiss) according to OECD Guideline
203 and US EPA OPPTS 850.1075, in compliance with GLP. In the study, the
fish were tested at nominal concentrations of 0.0 (negative control),
0.0 (solvent control), 9.4, 19, 38, 75, and 150 μg a.i./L in a
static-renewal system for 96 h, with renewals being performed every 24
h. Two replicate test chambers were maintained in each treatment and
control group, with 10 fish in each test chamber, for a total of 20 fish
per concentration. Mortality and signs of toxicity or abnormal behavior
were monitored at approximately 6, 24, 48, 72 and 96 h after test
initiation. The mean measured test concentrations were 7.2, 14, 30, 61
and 126 μg a.i /L, representing 77, 74, 79, 81 and 84% of nominal
values, respectively. The results of the study were calculated based on
mean measured concentrations. All water quality measurements remained
within acceptable limits. The concentrations of the test substance
remained stable over time under the conditions of administration,
ranging from 60 to 99% of nominal values during the study. All fish in
the negative control, solvent control, 7.2 and 14 μg a.i./L treatment
groups appeared normal and healthy throughout the test. Mortality in the
30, 61 and 126 μg a.i./L treatment groups was equivalent to 10, 45 and
70%, respectively. Signs of toxicity observed in the 61 and 126 μg
a.i./L treatment groups included lethargy and loss of equilibrium. The
96 h LC50value was determined as 76 μg a.i./L, with a 95%
confidence interval of 59 to 108 μg a.i./L (Thomas ST, 2012).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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