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EC number: 810-533-8
CAS number: 330459-31-9
The steady state BCF for PH label were 169 and 223 for the mean measured concentrations of 0.38 and 4.4 μg/L, while for the TH label were 201 and 307 for the mean measured concentrations of 0.34 and 4.3 μg/L. Chromatographic profiles of fish tissue extracts indicated that the test substance was rapidly metabolized to a complex mixture of metabolites. Significant amounts of radioactivity in fish tissues were non-extractable, indicating formation of bound residues.
study was conducted to assess the potential of the test substance for
bioaccumulation according to OECD Guideline 305 and US EPA OPPTS
850.1730, in compliance with GLP. The test was divided into two phases:
uptake (for 28 d) and depuration (for 35 d). During the uptake phase,
bluegill sunfish were exposed to two nominal test concentrations (0.6
and 6 μg a.i. /L) of each of two radiolabeled forms of the test
substance (phenyl (PH)- and thiophene (TH)-labeled). During both phases
of the test, test organisms and water samples were collected and
analyzed for total 14C radioactivity. Test organisms and water samples
were analyzed for parent compound during the uptake phase and for one
interval of the depuration phase. The determinations of the
concentrations of the radiolabeled test substances and/or metabolites in
freshwater and fish tissue were performed using LSC. These values were
used to determine the substance-specific half-life (t1/2), the kinetic
bioconcentration factor (BCFK) and the steady-state bioconcentration
factor (BCFSS) in fish, as well as lipid-normalized and growth-corrected
kinetic and steady-state bioconcentration factors (BCFSSL, BCFKL, BCFKg
and BCFKLG). Selected tissue samples were also extracted and analyzed by
HPLC in order to investigate the metabolism of the test substance in
fish. The mean measured (total radioactivity in tissues of fish)
concentrations for PH-labeled were 0.53 and 5.5 μg/L, and for TH-labeled
were 0.52 and 5.4 μg/L. Mean measured (in terms of parent compound in
tissues of fish) concentrations for PH-labeled were 0.38 and 4.4 μg/L,
and for TH-labeled were 0.34 and 4.3 μg/L. The steady state BCF for
PH-labeled were 169 and 223 L/kg, respectively, for the mean measured
concentrations of 0.38 and 4.4 μg/L, while for the TH-labeled were 201
and 307 L/kg, respectively, for the mean measured concentrations of 0.34
and 4.3 μg/L. Chromatographic profiles of fish tissue extracts indicated
that the test substance was rapidly metabolized to a complex mixture of
metabolites. Significant amounts of radioactivity in fish tissues were
non-extractable, indicating formation of bound residues (Schneider SZ,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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