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EC number: 942-925-0
CAS number: -
One group of female and male rats was nose-only exposed to the solid
aerosol of the test item at the maximum attainable concentration of 2590
mg/m³ in the animals breathing zone (limit test). In order to achieve
the required mass median aerodynamic diameter (MMAD) the test item was
micronized using a ball-mill. Rats of the control group were exposed to
air under otherwise identical circumstances.
The results can be summarized as follows:
The respirability of the aerosol was adequate and in compliance of test
guidelines [the mass median aerodynamic diameter (MMAD) was 3.86 µm, the
geometric standard deviation (GSD) was 2.59]. Efforts have been made to
generate the maximum attainable concentration of 2590 mg/m³ test item in
consideration of particle size distribution according OECD test
Mortality did not occur during the course of the study. All rats exposed
to 2590 mg/m³ revealed clinical symptoms (e.g. bradypnea, labored
breathing, irregular breathing, motility reduced, atony, high-legged
gait, cyanosis, piloerection, haircoat ungroomed, fur orange stained,
reduced reflexes). Furthermore animals exposed to the test item showed
significant reduction in incremental body weight gain and absolute body
weight when compared to control animals as well as significant decreased
body temperatures in comparison to controls. Gross pathological findings
were seen in all six animals exposed to 2590 mg/m3 on day 14
(light-colored areas and orangecolored areas in the lungs, orange
discolorations in the lung-associated lymph nodes).
In summary, there is evidence of low acute inhalation toxicity in rats
after exposure (4h) of the aerosolized test item. The LC50 is> 2590
A study on the acute inhalation toxicity of Zinc-Azo barbituric acid /
Melamine (henceforward referred to as test item) in rats has been
conducted in accordance with OECD TG#403 (2009). Test procedures were
adapted so as to comply also with the EU Directive 92/69/EEC, and
especially OECD GD#39 (2009). One group of female and male rats was
nose-only exposed to the solid aerosol of the test item at the maximum
attainable concentration of 2590 mg/m³ in the animals breathing zone
(limit test). In order to achieve the required mass median aerodynamic
diameter (MMAD) the test item was micronized using a ball-mill. Rats of
the control group were exposed to air under otherwise identical
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