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EC number: 932-084-8
CAS number: -
Results for the negative controls (spontaneous mutation rates) are
presented in Table 1 and were considered to be acceptable. These data
are for concurrent untreated control plates performed on the same day as
the Mutation Test.
The individual plate counts, the mean number of revertant colonies and
the standard deviations, for the test material, positive and vehicle
controls, both with and without metabolic activation, are presented in
Table 2 and Table 3 for Experiment 1 and Table 4 and Table 5 for
The vehicle (dimethyl sulphoxide) control plates gave counts of
revertant colonies within the normal range. All of the positive control
chemicals used in the test induced marked increases in the frequency of
revertant colonies, both with or without metabolic activation. Thus, the
sensitivity of the assay and the efficacy of the S9-mix were validated.
The test material caused no visible reduction in the growth of the
bacterial background lawn at any dose level and was, therefore, tested
up to the maximum recommended dose level of 5000 μg/plate.
No significant increases in the frequency of revertant colonies were
recorded for any of the bacterial strains, with any dose of the test
material, either with or without metabolic activation or exposure method.
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