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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
About the pharmacologic and toxic activities of E-Caprolactam.
Author:
Hohensee F.
Year:
1951
Bibliographic source:
Faserforschung und Textiltechnik 8, 299-303
Reference Type:
publication
Title:
About the pharmacologic and toxic activities of E-Caprolactam.
Author:
Hohensee, F.
Year:
1951
Bibliographic source:
Fiber Res. and Textile Tech. 1, 299-303. Cited in: Henschler, D. (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag Chemie (1991)

Materials and methods

Principles of method if other than guideline:
Eight mice each were injected subcutaneous daily with test substance at the rate of 50 and 150 mg/kg bw for 42 days. Three animals were kept as control.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
ε-caprolactam
EC Number:
203-313-2
EC Name:
ε-caprolactam
Cas Number:
105-60-2
Molecular formula:
C6H11NO
IUPAC Name:
azepan-2-one
Specific details on test material used for the study:
- Name of test material (as cited in study report): epsilon-Caprolactam

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Duration of treatment / exposure:
42 days
Frequency of treatment:
daily
Doses / concentrationsopen allclose all
Dose / conc.:
50 mg/kg bw/day
Dose / conc.:
150 mg/kg bw/day
No. of animals per sex per dose:
8
Control animals:
yes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No abnormalities were detected

Applicant's summary and conclusion

Conclusions:
No abnormalities were detected.
Executive summary:

Eight mice each were injected subcutaneous daily with test substance at the rate of 50 and 150 mg/kg bw for 42 days. Three animals were kept as control.

No abnormalities were detected