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EC number: 269-075-7
CAS number: 68187-15-5
An inorganic pigment that is the reaction product of high temperature calcination in which praseodymium (III) oxide, praseodymium (IV) oxide, silicon oxide, and zirconium (IV) oxide in varying amounts are homogeneously and ionically interdiffused to form a crystalline matrix of zircon. Its composition may include any one or a combination of the modifiers alkali or alkaline earth halides.
One reliable animal study, performed according to OECD guideline 429 and according to GLP, shows that zirconium praseodymium yellow zircon has no sensitising properties.
The positive control group caused the
expected increases in lymph node cell count and lymph node weight
(statistically significant at p≤ 0.01). The values for the stimulation
index of lymph node cell count and lymph node weight were 1.88 and 1.64,
respectively. Therefore, the study could be regarded as valid.
Zirconium praseodymim yellow zircon does not show respiratory sensitising properties in exposure related observations in humans.
The reference Haferkorn, J. (2010) is considered as key study on skin sensitisation and will be used for classification.
Under the present test conditions, Zirconium praseodymim yellow zircon at concentrations of 10 %, 25 % or 50 %(w/w) in acetone/olive oil (3 +/-, v7v) did not reveal any sensitising properties in the local lymph node assay. Therefore, the test item is not be classified and labelled according to regulation (EC) No.:1272/2008.
There is no evidence on specific respiratory hypersensitivity in humans following repeated inhalation exposure with zirconium praseodymim yellow zircon. Thus, the classification criteria acc. to regulation (EC) 1272/2008 as respiratory sensitiser are not met.
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