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EC number: 259-160-7 | CAS number: 54423-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to an U.S.E.P.A. TSCA Testing Guideline in compliance with the GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Healthy young adult rabbits were obtained from J. Leslie Furs, American Fork, Ut. that weighted 2.0 — 4.0 kg at time of dosing. The animals were acclimated for 8 days before being placed on study. Rabbits were Individually housed in stainless steel, wire mesh bottom cages. Animal room air was 100% fresh with not less than 10 air changes per hour. The temperature was maintained within protocol limits of 61 — 70°F and relative humiditywas 40 — 60%. Light: 12/12 hour, light/dark cycle was maintained. Fresh certified Agway rabbit feed was provided ad libitum and Fresh potable water was provided ad libitum.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent untreated skin site
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 6
- Details on study design:
- Approximately 19 hours prior to dermal administration, the hair was clipped from the dorsal area of the animals. Six rabbits were dosed with 0.5 ml of vinyl neononanoate on one intact skin site. The test substance was applied to the skin and covered with a gauze patch which was securely taped in place with hypoallergenic tape. The animals were then wrapped with an occlusive impervious, non—reactive rubberized material and securely taped in place for 4 hours. The animals were then unwrapped and the skin wiped with an absorbent pad to remove any remaining test substance. Observations for skin irritation were made at prescreen, within sixty minutes of compound removal (approximately 4 hours after dosing), 24 hours, 48 hours, 72 hours following patch removal and on Day 7, 10 and 14 of the study. Rabbit body weights were taken within 48 hours of receipt and prior to dosing. All animals were sacrificed following the day 14 scoring period.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 3
- Max. score:
- 3
- Irritant / corrosive response data:
- Mean dermal irritation scores reached their maximum at 24 hr The scores were 1.7 for erythema and 1.3 for edema. At study termination the scores were 0.7 for erythema and 0.7 for edema. Begining at day 10 dried skin was observed at the test site in two of the animals. This dried skin remained throughout the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Based on the classifications for the observation intervals listed vinyl neononanoate is considered to be a moderate skin irritant under the occlusive conditions of this test.
- Executive summary:
An U.S.E.P.A. OTS skin irritation Testing Guideline study was conducted on vinyl neononanoate under the GLP regulations. Based on the classifications for the observation intervals in this study vinyl neononanoate is considered to be a moderate skin irritant under the occlusive conditions of this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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