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EC number: 233-162-8
CAS number: 10049-04-4
No other information
dioxide was administered to Spague-Dawley pups rats by oral gavage at
dose level of 14 mg/kg bw/day during postnatal day 5 through 20.
male pups (8 per litter) were examined for selected neurodevelopmental
body weight was significantly decreased at PND 21 by direct exposure.
Exploratory behavior measured on PND 28 and 60 showed decreased in both
way of exposure.
activity measured from PND 5 to 20 (measurement per litter) and from PND
50 to 60 (individual measurement) showed a decrease on PND 18-19 and
contradictory results at PND 50-60.
The total DNA content of the cerebella was significantly reduced for
both the cerebellum and forebrain.
data indicate that rat pups exposed to ClO2 both exhibited
behavioral deficits and depressed brain growth, consistent with effects
produced by depressed thyroid function.
was determined to be 14 mg/kg bw/day.
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