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Description of key information

Chlorine dioxide  should not be considered as a substance with a carcinogenic potential.

Key value for chemical safety assessment

Justification for classification or non-classification

Harmonised classification:

The classification entered in the Annex VI to the CLP Regulation for Chlorine dioxide is not harmonised for the carcinogenicity category.


No self-classification is proposed

Additional information

There is no concern for carcinogenicity resulting from exposure to chlorine dioxide based on:

- the three studies used as a weight of evidence approach showing that the chlorine dioxide was not an initiator of the carcinogenesis and didn't induce lung adenoma. Therefore, chlorine dioxide is not implicated in the first step of the carcinogenesis.

- Chlorine dioxide has not a widespread dispersive use or there is no evidence of frequent or long-term human exposure and,

- the substance is not classified as mutagen, as chlorine dioxide has no mutagenic potential (see § 7.6).

Therefore, chlorine dioxide should not be considered as a substance with a carcinogenic potential.

Moreover, regarding the chlorine dioxide classification as corrosive and fatal by inhalation, the workers wear appropriate Protective Personal Equipments (mask and gloves) at the workplace. Hence, the workers are not exposed to the chlorine dioxide frequently or for a long period of time. Therefore, it is not deemed useful to perform a carcinogenicity study on the chlorine dioxide.