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EC number: 233-162-8
CAS number: 10049-04-4
Table 7.6.2/1:Table summarizing SCE frequencies in animals exposedin vivoto chlorine dioxide
No. of animals
No. of cells scored/animal
Total no. of cells scored
x ± S.E.
3.89 ± 0.26
13.15 ± 0.36*
3.50 ± 0.25
4.74 ± 1.29
3.73 ± 0.54
* significantly greater than negative control, p0.01
aOne animal had cell cycle delay, all cells in M1
bOne animal only 17 cells were scored
cone animal died after dosing
dmean SCE frequency / animal constituted a data point
In an in vivo genetic toxicity study,
Sister Chromatid Exchange (SCE) frequencies were determined in bone
marrow cells in ICR male mice exposed to Chlorine Dioxide administered
intraperitoneally as an acute dose, at dose levels of 9.04, 21.08,
28.02, 38.55 mg/kg in deionised water.
Animals were killed at 26 h post
implantation, the optimum time for detection of SCE and the cells
collected from the bone marrow. M2 cells were scored for the frequency
of SCE per cell.
Concurrent vehicle mice were considered as a
negative control. Cyclophosphamide was used as a positive control and
was administered by injection at 10 mg/kg in 0.9% saline.
Genotoxicity of Chlorine Dioxide was found
to be negative to bone marrow cells in ICR male mice and no toxicity
effects were found.
Positive controls induced the
The SCE frequencies were not significantly
increased in any of the dose groups relative to the negative controls
and were within the range of historical controls. The positive control
showed a strongly and significantly increased SCE frequency relative to
control. Chlorine dioxide did not induce significant
increases in SCEs at any of the doses tested.
Under the test conditions, Chlorine dioxide
is considered negative for inducing sister chromatid exchanges in male
mice bone marrow.
This study is considered as acceptable as
it satisfies with the requirements for Test Guideline OECD 479.
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