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EC number: 233-162-8
CAS number: 10049-04-4
In a subacute study, rats (5 per group) were
exposed to Chlorine Dioxide by gas inhalation at dose level of 0 and 10
ppm (0 and 28 mg/m3), 4 h/d for 9 days in a 13 -day period.
Urine was examined for protein, and the
weight of the rats was charted. At the end of the experiment, animals
were sacrified and kidneys, liver and lungs were examined at necropsy.
The exposed rats showed marked distress in
the form of rhinorrhea and embarrassed respiration.
The number of positive urinary protein tests
was not greater in the exposed rats than in the controls.
The weight of the exposed rats, however,
showed a mean reduction of about 80 mg, while that of the controls was
One rat died after 10 days' exposure, and
two died after a further day. The two remaining rats died on the 13th
The kidneys, liver, and lungs were examined.
In all the exposed rats microscopy showed changed resulting from
respiratory infection with acute renal and hepatic congestion.
The LOAEC in this study is 28 mg/m3,
based on respiratory effects.
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