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EC number: 233-162-8
CAS number: 10049-04-4
Acute toxicity: Oral: LD50 combined: 94 mg/kg bw (K, Reliability 1)
Acute toxicity: Dermal: not applicable as Chlorine dioxide is classified
Acute toxicity: Inhalation: LC50 combined: 89,6 mg/m3=32ppm (K,
Acute toxicity: oral
A study was identified as the key study
(Tos, 1996).The study was conducted according to the OECD guideline No.
401 and in compliance with GLP. Rats were administered Chlorine dioxide
(as a 0.2 % solution in water) by gavage at doses of 20, 40 and 80 mg/kg
Animals treated at the lowest dose showed
hypoactivity, piloerection and hunched posture during the first three
days of the study. Females treated at 40 mg/kg bw showed the same
clinical signs up to day 5 of the study. Males treated at 40 mg/kg bw
and all animals treated at the highest dose showed clinical signs
involving the CNS, the respiratory tract, and also piloerectoin, hunched
posture and salivation. All reviving animals recovered within days 4 -7
of the study. The autopsy of animals which died during the study showed
test substance-related changes in the gastrointestinal tract: congestion
and erosions with mucus or test substance presence in the stomach and
thinning walls with catarrhal or catarrhal-hemorrhagic content in the
intestine. Congestion of the lungs, of the kidneys and of the liver and
decreased size of the spleen were also observed. Animals treated at 20
mg/kg bw not show any necroscopic changes at the autopsy performed at
the end of the study. The surviving animals treated at the highest doses
(40 and 80 mg/kg bw) showed changes in the stomach (thickening of the
glandular mucosa) which were considered test substance related. Oral
LD50Combined = 93.86 mg/kg bw (95% C.L. of 45.52 -193.53
mg/kg bw). Observed effects are related to the corrosive properties
In accordance with column 2 of REACH
Annex VIII, the acute dermal toxicity study (required in section 8.5.3)
does not need to be conducted as the substance is classified as
corrosive to the skin based on the results of the acute oral toxicity
study of Tos (1996).
study was identified as the key study (Schorsch et al., 1996).
The study was conducted according to the EU Method B.2 and in compliance
with GLP. Rats were exposed by oro-nasal inhalation to Chlorine Dioxide
gas for 4 hours at analytical concentrations of 0, 46, 71, 107 and 128
signs observed in all dose groups included: respiratory distress
(abdominal respiration, noisy respiration, labored respiration and nasal
secretion) and general weakness (piloerection, hunched back, decrease of
activity and weight loss / thin body condition). Lungs from treated
animals showed frequent mottling, redness and depressed area. The main
lesion induced by ClO2 is the destruction of alveolar walls,
which created dose-related pulmonary emphysema lesions. Inhalation LC50combined
= 89 mg/m3 air (95% CL 69 -119 mg/m3).
dioxide 0.2% is classified for acute oral toxicity as:
3 (H301 Toxic if swallowed) according to the CLP Regulation (1272/2008)
as LD50was found to be between 50 and 300 mg/kg bw.
- Toxic if
swallowed (T; R25) according to the Directive 67/548/EC as LD50was
found to be between 25 and 200 mg/kg bw.
dioxide is classified for acute inhalation toxicity as:
toxic by inhalation (T+; R26) according to the Directive 67/548/EC as LD50was
found to be < 0.5 mg/L/4h (gas).
the results of the key study (Schorsch et al., 1996), Chlorine dioxide
is classified for acute inhalation toxicity as:
1 (H330 Fatal if inhaled) according to the CLP Regulation (1272/2008) as
LD50was found to be between 0 and 100 ppm (gas).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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