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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: human case
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Entry adopted from the OECD SIAR on sulfur dioxide without modification.well ducumented study

Data source

Reference
Reference Type:
publication
Title:
Effects of inhalation of sulphur dioxide by man
Author:
Amdur; M.O.; et al.
Year:
1953
Bibliographic source:
The Lancet, Oct. 10, 1953: 758

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study reports exposure- related observations in human: Respiratory response of man to low concentrations of sulfur dioxide.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): sulfur dioxide
No further details are given.

Method

Type of population:
general
occupational
Subjects:
no details given
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
Concentrations of sulfur dioxide were established in a 2c.ft. "Lucite" chamber by metering in diluted SO2 (1% in air) from a steel cylinder. The SO2 joined the main air stream before entering the chamber. The concentrations of SO2 in the chamber were measured.
The subjects of the experiment were at rest and breathed through a face-mask.
Examinations:
The volume of expired air was measured in a spirometer, which was read every minute. The respiratory rate and pattern were obtained with a pneumotachograph, a device for instantaneous recording of air-flow during breathing. From direct tracing the whole breathing pattern, inspiratory and expiratory flow-rates, and other breathing characteristics can be obtained.
Medical treatment:
no medication

Results and discussion

Clinical signs:
At 5 ppm most people complained of a slight feeling of dryness in the throat and upper respiratory passages, but they could not actually "smell" SO2. One person found at 5 ppm so objectionable that the exposure was stopped after 5 minutes, whereas other barely noticed it. People exposed to 6-8 ppm definitely detected SO2 in the air but said they became accustomed to it as the exposure continued.
Results of examinations:
14 normal people exposed to SO2 1-8 ppm showed changes in respiration and pulse-rate. Tidal volume decreased, respiratory rate increased, minute volume remained unchanged, and pulse rate increased.
Effectivity of medical treatment:
no medication

Applicant's summary and conclusion

Conclusions:
At 5 ppm most people complained of a slight feeling of dryness in the throat and upper respiratory passages, but they could not actually "smell" SO2. One person found at 5 ppm so objectionable that the exposure was stopped after 5 minutes, whereas other barely noticed it. People exposed to 6-8 ppm definitely detected SO2 in the air but said they became accustomed to it as the exposure continued.