Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid
EC Number:
700-144-0
Cas Number:
13115-71-4
Molecular formula:
C7H13N3O4
IUPAC Name:
(2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The results of this study show that the test substance Glycyl-L-glutamine monohydrate induced no immobilisation to the exposed Daphnia within 48 hours. The EC50 value after 2 days of exposure was >100 mg AI/L and the NOEC was ≥ 100 mg AI/L, respectively.
As analytical determination showed no relevant loss of test substance during the first and the second exposure interval EC values were based on nominal concentration.