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EC number: 256-032-2
CAS number: 42978-66-5
Acute dermal toxicity was investigated with 10 albino rabbits (five/sex)
treated with a single dose of 2000 mg/kg similar to OECD protocol of
guideline 402 (GLP not specified, reliability 2). Single occlusive
dosing at a dose volume of 1.9 ml/kg was performed on abraded skin for
24 hours. Under this study conditions no mortality was observed during
the observation period of 14 days. Four males and three females
exhibited slight weight gains, whereas one male and one female rabbit
exhibited no net change in theig bodyweight. One female animal exhibited
a weight loss, however, this animal was noted to have a possible broken
leg or lower lack injury during the second week of the study. Well
defined to severe erythema accompanied by very slight or moderate edema
were observed in males after 24 hours. Females exhibited very slight or
well-defined erythema accompanied by severe edema. No abnormalities of
clinical signs were noted during the four hours after dosing. Three
males exhibited fecal staining at 24 hours and one female exhibited this
sign at 24 hours and on Day 2. One female exhibited decreased food
consumption at 24 hours. One female exhibited clear nasal discharge on a
single occasion and clear ocrilar discharge on several occasions.
Another female was noted to have an apparent broken leg or lower back on
Day 9 and exhibited soft stool, fecal staining and/or urinary staining,
decreased food consumption, decreased activity and/or prostration from
Day 9 through termination. Six of the tested ten animals had gross
pathology findings which included: 5/10 animals with slightly irregular,
slightly diminished or purplish spleen, 2/10 animals mottled pale liver
(20%-40%), 2/10 animals with pale kidneys, 1/10 animals with slight
fecal staining, 1/10 animals with empty stomach, 1/10 animals with
Due to the abscence of mortality under the tested conditions of this
study no LD50 value was derived.
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