Registration Dossier
Registration Dossier
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EC number: 201-148-0 | CAS number: 78-83-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- "Ethnic contact urticaria to alcohol
- Author:
- Wilkin, J.K. and Fortner G.
- Year:
- 1 985
- Bibliographic source:
- Contact Dermatitis : Environmental and Occupational Dermatitis, Vol . 112, pp. 118-120; cited in OECD SIDS "Isobutanol", Final September 2004
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: Asian subjects who previously had reported severe facial flushing in response to oral ethanol ingestion
- Principles of method if other than guideline:
- Patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylpropan-1-ol
- EC Number:
- 201-148-0
- EC Name:
- 2-methylpropan-1-ol
- Cas Number:
- 78-83-1
- Molecular formula:
- C4H10O
- IUPAC Name:
- 2-methylpropan-1-ol
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 3
- Demographic information: asian - Clinical history:
- - History of allergy or casuistics for study subject or populations: severe facial flushing in response to oral ethanol ingestion
- Controls:
- Ethanol was used as a positive control agent
- Route of administration:
- dermal
- Details on study design:
- The skin was rated for the presence or absence of erythema immediately post-exposure.
Results and discussion
- Results of examinations:
- Dermal isobutanol exposure did not cause erythema in any of the test subjects. Ethanol was positive for erythema in these same test subjects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
