Registration Dossier
Registration Dossier
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EC number: 202-509-5 | CAS number: 96-48-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitizing potential of y-Butyrolactone (GBL) was assessed using the radioactive Murine Local Lymph Node Assay and was determined not to be a skin sensitizer (BASF SE, 2010).
Migrated from Short description of key information:
Not a sensitiser
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
y-Butyrolactone (GBL) has not been specifically tested for respiratory sensitization but the many years of human experience handling this substance, along with information on metabolism and the absence of a skin sensitisation potential, provides sufficient evidence that it is not a respiratory sensitiser.
Migrated from Short description of key information:
Not expected to be a sensitiser
Justification for classification or non-classification
Based on the results of a Local Lymph node assay gamma-butyrolactone is judged not to be a skin sensitizer under the EU DSD criteria (EU Directive 67/548/EEC) or the EU CLP criteria (EU Regulation 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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