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EC number: 249-079-5
CAS number: 28553-12-0
In an in vivo cytogenetic assay, DINP (R-1218, CAS 28553-12-0) was
administered orally to 3 groups of Fisher 344 rat at doses of 5-1.7-0.5
ml/kg/d, diluted in corn oil, during 5 days (Microbiological Associates,
1981d). Samples of femoral bone marrow were analysed for chromosomal
aberrations after the treatment period. Concurrent olive oil and
triethylenemelamine dosed animals served as negative and positive
controls, respectively. In a preliminary range finding study, no toxic
effects were detected at levels up to 10 ml/kg DINP. There were no
changes in the mitotic index at any dose tested. No changes were
observed (only one animal had chromosomal abnormality at dose of 1.7
mg/kg/d (chromatid breaks) and the test was considered to be negative.
However, cytogenetic analysis has been performed on only 50 cells/animal
and mitotic index calculated by observation of 100 cells only, such
values are low and can weaken the significance of the test.
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