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EC number: 249-079-5
CAS number: 28553-12-0
There was no evidence of systemic toxicity from repeated dermal
exposures to MRD-69-4 as based on general appearance and behavior,
clinical laboratory studies, and gross and microscopic visceral
Compound effect was confined to gross and microscopic alterations of the
skin. Grossly, MRD-69-4 at the 0.5 ml/kg/day level produced generally
mild dermal irritation which was slightly more severe than irritation
produced by mineral oil at 2.5 ml/kg/day; at the 2.5 ml/kg/day level,
slight or moderate (abraded skin only) erythema and slight desquamation
were noted through the fifth week of application.
Histologically, skin sections showed slight acanthosis, slight
hyperkeratosis, and slight dermatitis of comparable severity in control
and compound-treated animals. Sections of kidney, liver, and skin from
control and test animals were comparable histologically; lesions
encountered were consistent with incidental disease.
In a six week dermal toxicity study, groups of four New Zealand White
rabbits received 24-hour daily applications of MRD-69-4 at 0.5 or 2.5
ml/Kg, five times a week, to the closely clipped intact (two animals per
group) or abraded (two animals per group) abdominal skin, wrapped with
gauze adhesive tape and fitted with neck collars. Control animals (three
males and one female) received mineral oil at 2.5 ml/Kg. Clinical signs
were recorded daily, haematology and urinalysis undertaken initially and
terminally, and histopathology was performed on the liver, kidneys and
skin. There was no evidence of systemic toxicity. Mild irritation was
observed at the application sites of animals treated with MRD-69-4,
although there was no difference in the severity of histopathological
skin changes apparent between test and control animals. The systemic
NOEL was considered to be 2.5 ml/kg/day (estimated to be 2500 mg/kg/day)
and the local NOAEL was considered to be 0.5 mg/kg/day (estimated to be
The dermal toxicity study was considered to be a suitable supporting
study for classification.
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