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EC number: 249-079-5
CAS number: 28553-12-0
In a 2-week study
(General Motors Research Laboratories, 1981) designed to evaluate the
fate of DIDP (see Section 5.1), toxicity was also assessed. DIDP was
administered to 8 male rats (6 for control) by inhalation (aerosol) at
analytical concentration of 505±7 mg/m3(MMAD: 0.98 μm) 6
hours a day, 5 times per week. Rats were observed daily for body weight
gain, appearance and gross behavior. Animals were sacrificed at the end
of the observation period (3 weeks) and tissue samples taken for
histopathology. There were no marked outward signs of toxicity during
exposure. The rate of body weight gain was not different between control
and exposed animals. Effects in the lungs were: moderate increase in the
width of alveolar septa with slight interstitial mixed inflammatory
reactions, alveolar macrophages and type II pneumocytes were increased
in number, peribronchial lymphoid tissue appeared slightly more
prominent. In liver, spleen and kidneys, no obvious histologic
alterations were noted except for a slight hepatic fatty metamorphosis.
No systemic toxicity, but local irritant effects were observed at the
concentration tested, thus a NOAEL of 0.5 mg/l (500 mg/m3)
can be assumed.
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