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EC number: 249-079-5
CAS number: 28553-12-0
LC50 > 4.4 mg/l (nominal concentration) (Hazleton, 1980) DINP (no
information on the CAS number) was administered as an aerosol to ten
Sprague- Dawley rats (5 males and 5 females) at a nominal concentration
of 4.40 mg/l which was according to the testing facility the highest
attainable concentration in air during 4 hours (The report has
conflicting information as once in the report a nominal concentration of
5.0 -5.5 mg/l is listed, however on two other pages the nominal
concentration is indicated to be 4.40 mg/l). Gravimetric evaluation of
the aerosol resulted in concentrations of approx. 1.7 mg/l. Particle
sizing was also undertaken showing that majority of teh non-volatile
mass collected by the mini-impactor was in the respirable range (i.e.
less than 5 micron). A control group of ten Sprague-Dawley rats (5 males
and 5 females) received air. The observation period was 14 days. All
treated animals were observed to have slight tearing of the eyes and
slight clear nasal discharge starting 40 minutes after exposure was
initiated. One male was observed to have blood around both eyes on day 4
and a slight brownish discharge around both eyes on days 5 to 10; from
day 8 to 10, this animal had developed an opaque spot on one eye. All
other animals exhibited normal behaviour and appearance throughout the
exposure period. No animal died during this study, no definite
compound-related changes of body weight, no consistent compound-related
gross lesions, no compound-related microscopic alterations of lungs,
liver and kidneys in the treated animals were observed.
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