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EC number: 249-079-5
CAS number: 28553-12-0
Like other high molecular weight phthalate esters, DINP was observed to
have a low order of toxicity by the inhalation, dermal, oral routes of
exposure in acute toxicity animal studies with LD50/LC50 values
exceeding the maximum amounts that can be administered to test animals
(ExxonMobil., 1968a,b; BASF, 1981a,b). For example, in oral studies, no
significant signs of toxicity are reported, even in studies using doses
well above the limit dose recommended by current regulatory guidelines.
In dermal studies, limited reversible irritation is the only effect
associated with treatment.
Due to their low vapor pressures and the technical difficulties of
generating a vapor at ambient temperatures, few studies by the
inhalation route of exposure are available, most of which are relatively
old and conducted before the development of testing guidelines or the
implementation of good laboratory practice procedures. Although poorly
documented, there were no reports of body weight changes, gross lesions
or microscopic alterations of lungs; only slight tearing of the eye and
slight clear nasal discharge when animals were exposed to DINP at the
saturated vapor concentration. As reported in the European Union Risk
Assessment for DINP, the LC50 for an aerosol is greater than 4.4 mg/l
No classification for acute toxicity is indicated according to the
general classification and labeling requirements for dangerous
substances and preparations (Directive 67-548-EEC) or the
classification, labeling and packaging (CLP) regulation (EC) No
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