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EC number: 249-079-5
CAS number: 28553-12-0
A summary of the recovery of radioactivity following dermal application
of 14C-DINP is appended in the 'Overall remarks, and attachments' window
Absorption of 14C-D1NP was slow as indicated by
the recovery of only ~ 0.3% of applied doses in urine, feces, GI tract,
and tissue at 24 hr following treatment. The rates of absorption
increased slightly between 3 and 7 days following treatment, but the
total absorption did not exceed 4% of the administered doses in rats
receiving the high dose. Similar amounts (~3%) were absorbed during a
7-day period following treatment with the lower dose. Most of the
applied radioactivity was recovered from the application areas (skin and
cover). Blood and tissue contained low levels of radioactivity. Skin
from non-application areas demonstrated the highest levels followed by
variable amounts in livers, muscle, and fat . Tissue Levels were
slightly higher at 3 and 7 days than at 1 day following treatment. No
major differences were demonstrated in tissue levels or excretion rates
of 14C-DINP in rats treated under the conditions
used in this study.
In a 7-day dermal disposition study, 14C-DINP was applied to freshly
shaven areas on the backs of three groups of 3 or 6 male rats (Fischer
344) at 0.1 or 0.2 ml/rat (~1.2 ml/kg) . Rats were sacrificed at 1, 3,
or 7 days after treatment, and levels of radioactivity determined in
excreta, GI tract, blood and selected tissues. Dermal absorption of
14C-DINP was slow but occurred at a steady rate as evidenced by the
increased amounts of radioactivity recovered in urine, faeces, and
tissues examined at the later time periods. However, the total amounts
absorbed during the 7-day period ranged from 2 to 4% of the applied
doses. Dermal absorption was therefore considered to be very low in
rats, and most of the unabsorbed dose remained at the dermal application
site. Assuming a treatment area of 12 cm2 (3 x 4 cm) and a total
fraction absorbed of 3% in 7 days, the overall rate of dermal absorption
= 0.03 /(7 days)(24 hr/day)(12 cm2) = 1.5x10^-5 /hr/cm2.
The dermal disposition study is considered acceptable and satisfies the
guideline requirements for in vivo skin absorption studies.
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