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EC number: 249-079-5
CAS number: 28553-12-0
This study was designed to assess the extent of gastrointestinal
absorption, the distribution in selected tissues, and the rate and
routes of excretion of [14C] DINP (CAS 68515 -48 -0) following oral
administration to male albino rats weighing approximately 200 grams each
(4 treated rats, 2 controls). Four animals received 0.5 ml of "cold"
compound daily for five days and on the sixth day, they were dosed via
oral intubation with 0.5 ml of "hot" compound (about 2,500 mg/kg/d).
Expired gases, fecal and urinary excreta were collected separately, at
12 hours intervals, during the entire study period (72 hours).
Recordings were made of animal appearance and behaviour, body weights,
volumes of urine excreted, weights of feces excreted, and amounts of
food consumed. Seventy-two hours after intubation, the animals were
sacrificed and gross pathological observations were made. Blood and
urine remaining in the bladder were collected. The hearts, livers,
kidneys, intestines, stomachs and aliquots of fat and muscle were
removed and weighed. The contents of the intestines and stomach were
separated from their respective walls. The remaining viscera and carcass
from each animal were combined and weighed.
During the six-day period, all the animals exhibited a normal behaviour.
All animals gained weight during the five-day period when they were
given the cold compound. During the 72 hours after the administration of
the "hot" compound, one test animal and one control animal lost weight,
and the test animals consumed more food and excreted more feces than the
controls, but the controls excreted more urine than the test animals.
The amount of compound excreted in the urine within 72 hours ranged from
8% to 18.34% of the administered dose. The majority of the radioactivity
found was excreted in the first collection (12 hours). Thereafter, the
amount of radioactivity found fell off rapidly so that by the 72-hour
collection period less than 0.1% of the dose was found in all animals
except in one animal.
Over 80% of the administered dose was excreted in the feces and most of
the radioactivity was excreted within 24-hours after dosing. Between the
60- and 72-hour postdosage period no animal excreted over 0.2% of the
At sacrifice the tissues and organs of all animals appeared normal when
examined for gross pathological conditions. No tissue studied had over
0.001% per gram of the administered dose. On a total sample basis,
residual amounts of radioactivity were found in the gastrointestinal
tract of each animal. Of the selected organs, the liver contained the
most radioactivity (i.e. 0.010% mean). Most of the radioactivity
retained by the animals was found in the carcass and remaining viscera
(i.e. 0.060% of the administered dose).
No expired [14C] DINP was detected.
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