Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

DINP will not produce chronic toxicity to fish.

Key value for chemical safety assessment

Additional information

The result of long-term toxicity study is reported as a NOEC value for chronic fish toxicity. The NOEC value from this feeding study represents the highest concentration tested and measured under the conditions of the study. The results show that DINP does not cause toxicity. Additionally, the results can be used to assess the potential for endocrine disruption in fish. The multi-generation feeding study with Oryzias latipes (Medaka, 284-days) was conducted by adding DINP to dry flake food at 20 mg/kg. Evaluation of F1 and F2 embryos showed normal development except for a transient decrease in red blood cell pigmentation, which was observed in both the acetone control and DINP treatment groups. The only histopathological change observed in the F0 adults was a minor alteration in hepatocellular staining around the central vein. The male to female ratios (3:1) in all groups were similar. Phenotypic gender classifications of male and female fish were histopathologically confirmed to be 100% correct. The gonadal and liver somatic indices were not significantly different in the DINP treated group. There were no statistically significant changes in mortality, fecundity, or egg production between the treatment groups.