Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-079-5
CAS number: 28553-12-0
DINP will not produce chronic toxicity to fish.
result of long-term toxicity study is reported as a NOEC value for
chronic fish toxicity. The NOEC value from this feeding study represents
the highest concentration tested and measured under the conditions of
the study. The results
show that DINP does not cause toxicity.
Additionally, the results can
be used to assess the potential for endocrine disruption in fish.
multi-generation feeding study with Oryzias latipes (Medaka,
conducted by adding DINP to dry flake food at 20 mg/kg. Evaluation of F1
and F2 embryos showed normal development except for a transient decrease
in red blood cell pigmentation, which was observed in both the acetone
control and DINP treatment groups. The
only histopathological change observed in the F0 adults was a minor
alteration in hepatocellular staining around the central vein. The male
to female ratios (3:1) in all groups were similar. Phenotypic gender
classifications of male and female fish were histopathologically
confirmed to be 100% correct. The
gonadal and liver somatic indices were not significantly different in
the DINP treated group. There
were no statistically significant changes in mortality, fecundity, or
egg production between the treatment groups.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again