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EC number: 249-079-5
CAS number: 28553-12-0
DINP is not persistent (P) or very persistent (vP) based on standard
test guideline results.
DINP is not bioaccumulative (B) or very bioaccumulative (vB) based on
results from a fish dietary lab study, a food-web field study, and a
calculated bioconcentration (BCF) factor.
The low water solubility and high Kowof
DINP prevent conducting an aqueous exposure BCF study. However, there
are sufficient data available fromstudies to conduct a
weight-of-evidence assessment ofthe
potential of DINP to bioconcentrate. A fish dietary bioaccumulation
study demonstrated that DINP exhibited limited bioaccumulation based on
a lipid normalized biomagnification factor (BMF or concentration ratio
in tissue to that in diet) of <0.1 and rapid subsequent depuration with
a tissue elimination half-life of <1 day (ExxonMobil
Biomedical Sciences, Inc., 2002).
Study results showed that lipid equivalent concentrations of DINP
significantly declined with increasing trophic level and demonstrated a
food-web magnification factor (FWMF) or trophic magnification factor
(TMF) of 0.46(Mackintoshet al., 2004).
DINP is not toxic (T) based on results from chronic aquatic toxicity
studies that show no effects at levels equal to or even exceeding its
maximum water solubility and mammalian toxicity studies that support not
classifying DINP as carcinogenic, mutagenic, toxic for reproduction, or
assigning classifications of T, R48 or Xn, R48.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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