Registration Dossier
Registration Dossier
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EC number: 249-079-5 | CAS number: 28553-12-0
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
DINP is not persistent (P) or very persistent (vP) based on standard test guideline results.
DINP is not bioaccumulative (B) or very bioaccumulative (vB) based on results from a fish dietary lab study, a
food-web field study, and a calculated bioconcentration (BCF) factor.
The low water solubility and high Kowof DINP prevent conducting an aqueous exposure BCF study. However, there are sufficient data available fromstudies to conduct a weight-of-evidence assessment ofthe potential of DINP to bioconcentrate. A fish dietary bioaccumulation study demonstrated that DINP exhibited limited bioaccumulation based on a lipid normalized biomagnification factor (BMF or concentration ratio in tissue to that in diet) of <0.1 and rapid subsequent depuration with a tissue elimination half-life of <1 day (ExxonMobil Biomedical Sciences, Inc., 2002).Study results showed that lipid equivalent concentrations of DINP significantly declined with increasing trophic level and demonstrated a food-web magnification factor (FWMF) or trophic magnification factor (TMF) of 0.46(Mackintoshet al., 2004).
DINP is not toxic (T) based on results from chronic aquatic toxicity studies that show no effects at levels equal
to or even exceeding its maximum water solubility and mammalian toxicity studies that support not classifying
DINP as carcinogenic, mutagenic, toxic for reproduction, or assigning classifications of T, R48 or Xn, R48.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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