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EC number: 271-974-4
CAS number: 68647-86-9
groups, each consisting of three female RccHan:WIST (SPF) rats, were
treated with Coconut Shell Charcoal by single oral gavage administration
at a dosage of 2000 mg/kg body weight. The test item was formulated in
PEG 300 at a concentration of 0.2 g/mL and administered at a dosing
volume of 10 mL/kg.
animals were examined daily during the acclimatization period and
mortality, viability and clinical signs were recorded. All animals were
examined for clinical signs before treatment, within the first 30
minutes and approximately 1, 2, 3 and 5 hours after treatment on day 1
and once daily during test days 2-15. Mortality/viability was recorded
before treatment, within the first 30 minutes and approximately 1, 2, 3
and 5 hours after administration on test day 1 (with the clinical signs)
and twice daily during days 2-15. Body weights were recorded on day 1
(prior to administration) and on days 8 and 15.All animals were
necropsied and examined macroscopically.
intercurrent deaths occurred during the course of the study.
animals excreted feces stained in black one day after the administration
(test day 2). No other clinical signs were observed during the course of
animal showed a slight loss of body weight (-1.7%) from test day 8 to
day 15. Otherwise,the body weight of the animals was within the range
commonly recorded for this strain and age.
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