Registration Dossier
Registration Dossier
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EC number: 266-925-9 | CAS number: 67701-01-3 This substance is identified by SDA Substance Name: C12-C18 alkyl carboxylic acid and SDA Reporting Number: 16-005-00.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Assoc J. 1962 Mar-Apr;23:95-107
Materials and methods
- Principles of method if other than guideline:
- Inhalation Risk Test, where animals were exposed to a flowing stream of saturated vapour for up to 8 hours. The inhalation period is defined by killing half of the animals within a 14 day recovery period.
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test (IRT)
- Limit test:
- yes
Test material
- Reference substance name:
- Octanoic acid
- EC Number:
- 204-677-5
- EC Name:
- Octanoic acid
- Cas Number:
- 124-07-2
- Molecular formula:
- C8H16O2
- IUPAC Name:
- octanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Octanoic Acid (mixed isomers)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: dried room air
- System of generating vapour: by passing 2.5 L/minute dried room air through a fritted glass disc immersed to a deep at least 1 inch in approx. 50 ml of test substance contained in a gas-washing bottle - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 0.1621 mg/l (Danish EPA QSAR database, 2004 )
- No. of animals per sex per dose:
- 6 males or females
- Control animals:
- other: analogue tests with other substances were also reported
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.162 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: vapour
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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